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While there is ample evidence that B12, as an essential vitamin, has numerous health benefits, there is no evidence that B12 shots have greater benefit than a B12 supplement in pill form

The brain doesn't stop making neurotransmitters entirely, but the output is reduced, and the balance shifts in ways that can show up as anxiety, low mood, or both simultaneously

McCleery J, Abraham RP, Denton DA, et al

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Sources Novo Nordisk Ozempic: Using your Ozempic pen Mayo Clinic: Semaglutide (Subcutaneous Route) Side Effects FDA Access Data: Ozempic Label Pharmacy Times: InjectionSite Reactions and How to Manage Them (covers pain, swelling, itching, bruising, and prevention techniques) Cleveland Clinic Health Library: Semaglutide (Ozempic): How It Works & Side Effects (includes injectionsite itching, redness, rash) Journal of the American Academy of Dermatology: Dermatologic findings associated with semaglutide use: A scoping review (JAAD)