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The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (Figure 1)

most prevalent in older adults

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Randomly assigned to receive daily placebo or teriparatide as part of the Fracture Prevention Trial (20 g), participants were observed for an average of 24 months

The question remains whether PET in the bloodstream contributes to this accumulation and could thereby increase tissue burdens beyond a harmful threshold