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Long-term use of NSAIDs can lead to impaired glomerular filtration, renal tubular necrosis, and ultimately chronic renal failure by disrupting prostaglandin synthesis, which can impair renal blood flow (Weir 2002)

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[Abstract]2023 Nov 15;125(Pt B):111175

They can be solid or fluid-filled, and the majority of nodules do not cause symptoms or complications

Dec 2019;23(4):1047-1057

This is especially useful for compounds such as siRNA, miRNA and chemotherapeutic agents that need to act on the target at a site in order to reduce off-target effects
