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C3 convertase promotes C3 activation, a central component of CS signaling pathways

A specific type of autophagy mediated through the nuclear receptor co-activator 4 (NCOA4, a cargo receptor) called ferritin autophagy degrades ferritin, which in turn increases the size of the unstable iron pool in the cytoplasm to induce ferroptosis (18)

Although MPO plays a critical role in host defense, its overexpression leads to excessive ROS production, contributing to oxidative stress and tissue damage [44, 45]

10.1177/1559325818761455 47 FatimaU.RoyS.AhmadS.AliS.ElkadyW

The synthesis of enzymes required for DNA replication is also hindered by irradiation, thereby stopping mitotic divisions (Ahmed, 2005)

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