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Dunaevsky et al., Active targeted macrophage-mediated delivery of catalase to affected brain regions in models of Parkinsons disease

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Most ALS cases showed lumbar (34.0%), bulbar (31.0%) or cervical (25.5%) onset

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This stretch of residues includes a Gly-Pro-Gly motif with the G324 displaying the maximal C deviation of 2.4 , allowing the F325 (C shift of 1.6 ) to facilitate edge-to-face aromatic interactions with DA, which are absent in the NE-bound structure (Fig