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Immunogenic cell death (ICD) can trigger the release of tumor-associated antigens and damage-associated molecular patterns (DAMPs), remodel the tumor microenvironment by promoting dendritic cell activation and initiating cytotoxic T cell responses, potentially converting cold tumors into hot tumors and thereby enhance durable antitumor immunity

Lifestyle factors such as poor diet, lack of exercise, and excessive alcohol consumption

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Subsequently, Moody et al (85) extended these studies and synthesized VIP-camptothecin (CPT) conjugates that contain a novel carbamate linker with a built-in nucleophile associated releasing group, L2

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HCC patients exhibit significantly reduced gut flora diversity and altered composition