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This makes pharmacovigilance an important area of focus

Furthermore, the use of antioxidants can inhibit tumorigenesis by preventing OS caused by various causes, and the mechanism is to repair damaged DNA and inhibit cancer occurrence, including gene mutations, oxidative chromosomal damage, and lipid peroxidation of cell membranes (131, 363)

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These results indicate that oxidative stress participate in the pathophysiological cardiac dysfunction in heart failure [136]

doi: 10.1074/jbc.M808515200

Each isoform has specialized functions, with SIRT1 extensively studied for its roles in aging and metabolic diseases