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Acknowledgements None Funding This study was supported by grants from the National Natural Science Foundation of China (82060070), and Jiangxi Natural Science Foundation (20192ACBL20033), and the National Natural Science Foundation of China,82060070,Jiangxi Natural Science Foundation,20192ACBL20033,the Key Research and Development Program of Jiangxi Province,20202BBGL73069,the Second Affiliated Hospital of Nanchang University Funded Clinical Research Projects,2021efyC01,the General Science and Technology Program of Jiangxi Provincial Health Commission (No

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