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Schucht P, Raineteau O, Schwab OE, Fouad K

Because lipid peroxidation is likely to be involved in ASD, the aliphatic aldehydes, which are insufficiently neutralized by the cellular defense mechanisms, diffuse and begin to impair the function of membrane proteins and spread the damage to other neighboring cells

From hormone regulation and immune response to cell signaling, peptides are involved in nearly every function of the body

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Circulation 141 , 16621664 (2020)

In cellular models of ALS the RNA processing gets severely impaired upon oxidative stress, in turn causing the mis-localization of TDP-43 and FUS ( Another major factor contributing to the pathophysiological mechanisms in ALS is excitotoxicity, triggered by excessive postsynaptic glutamate receptor stimulation