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Funding This study was supported by the Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University, China (No

Choi and Park, 2018) (Table 2)

Exercise regularly and maintain an active lifestyle

and plasma and erythrocyte analysis of cobalamin coenzymes, which can reveal deficiencies of methylcobalamin or adenosylcobalamin

The tissues were rinsed with PBS and incubated with Alexa Fluor488 chicken anti-rabbit (1:1000, Life Technologies) for one hour at 37 C and then rinsed with PBS and incubated with Alexa Fluor488 goat anti-chicken antibody (1:1000, Life Technologies) and Alexa Fluor568 goat anti-mouse antibody (1:1000, Life Technologies) for another hour at 37 C

PROTAC degraders offer several advantages over traditional small molecule inhibitors, including its intrinsic event-driven pharmacology and nonlinear pharmacodynamics, improved safety profiles, and reduced risk of drug resistance