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During ferroptosis, dysregulated expression of ferritin heavy chain 1 (FTH-1) and transferrin receptor 1 (TFR-1) culminates in ferrous iron accumulation, which drives the generation of reactive oxygen species (ROS) via the Fenton reaction (17)

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Glutathione (see the Pentose Phosphate Pathway page) is important in maintaining the normal reduction potential of cells and provides the reducing equivalents for glutathione peroxidase to convert hydrogen peroxide to water

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