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These peripheral pro-inflammatory cytokines, including IL-8 and TNF-, are also elevated in brain tissue and cerebrospinal fluid, suggesting that systemic inflammation may influence central nervous system (CNS) function either through blood-brain barrier (BBB) leakage or active transport (Matta et al., 2019
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Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, et al
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The comprehensive biosafety of ZMTP nanosheet has been further investigated in normal mice without establishing AIA model
Mol Genet Metab 91:228233
