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Mechanisms and epidemiology Nociplastic pain stems from central sensitization, involving abnormal pain processing in the peripheral and central nervous systems, leading to increased sensitivity and reduced inhibition

Top C, Yildiz S, Oncl O, Qydedi T, Cevikba A, Soyogul UG, et al

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Nat Genet (2011) 43:24652

Despite advancements in metabolomics, which reveal changes in metabolites, a deeper understanding of the biological mechanisms behind these changes and metabolic regulatory processes is still lacking

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