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This was evidenced by in vivo studies, which revealed a markedly reduced expression of PGC-1 and its target genes in the striatum and muscle of HD mice ( A number of in vivo studies have demonstrated that mHtt is involved in the process of mitophagy or regulates intermediately important aspects in animal models of HD

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[DOI] [PubMed] [Google Scholar] 133.Cohen MA, Ellis SM, Le Roux CW, et al

Recruitment of Scientific Board Members and Panelists The scientific board members were invited by the leading authors (RO and KR) based on medical expertise, practical experience in the field of B12 deficiency, publication records, seniority, and willingness to participate