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GiorgioVMieleLPrincipessaLFerrettiFVillaMPNegroVet al
Parenteral administration of minute amounts of endotoxins to humans elicits an inflammatory reaction typical of SIRS (fever or hypothermia, tachycardia, hyperpnea, leukocytosis, and hypotension), whereas larger amounts of administered endotoxins typically produce sepsis and shock [66, 67]
However, its complex pharmacological activity and limited solubility have hindered its clinical application (Boulos et al., 2019)
PubMed: PMID 30512345
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