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Drug Metab Dispos 39:14951502

the second is that the long-term stimuli-increased secretory activity leads to a depletion of the releasable insulin of -cells 31

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doi: 10.1016/j.tins.2022.11.007 40

Association of low Dietary Folate Intake with lower Camkk2 gene methylation, adiposity, and insulin resistance in obese subjects

However, at this time, we cannot discriminate whether the epigenetic modifications are the cause or the consequence of the disease