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Together, these multiple mechanisms contribute to the efficacy of daratumumab, which was proven in the subsequent clinical trials as an effective and durable antitumor drug in MM patients

Accumulated preclinical and first clinical data indicate that MNPs are capable of accumulating in renal tissue, inducing mitochondrial dysfunction, ERstress, inflammation, autophagy, and fibrosis

In response to bleomycin, Gpx3 was upregulated also in tissue, albeit to a lesser extent compared to the increase in BALF, while Sod3 was largely unchanged, except during initial acute lung injury (Fig

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In the cytoplasm, DSF is expected to undergo rapid metabolism via thiol-disulfide exchange with endogenous thiols such as bacillithiol (BSH) and cysteine 17