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The reduced ability to synthesize GSH due to the low content and activity of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), which binds the promoter, is responsible for the low level of cytosolic GSH in neurons

Gadolinium chloride reduces cytochrome P450: Relevance to chemical-induced hepatotoxicity

Significance In conclusion, NPW facilitated the healing of gastric injury in rats via the inhibition of pro-inflammatory cytokine production, oxidative stress and neutrophil infiltration as well as the downregulation of COX-2 protein and NF-B gene expressions

T2*-weighted MRI values correlate with motor and cognitive dysfunction in Parkinsons disease

Patients with T2DM and ED showed significantly increased circulating monocyte oxidative activity compared to those without ED [9]

GSTs also have roles in detoxifying oxidative-stress metabolites, as well as having essential roles in leukotriene biosynthesis [1,3]