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High levels of S1P in fact have been found in the peritoneal environment of women suffering of endometriosis, showing the capability to induce differentiation of macrophages into CD163 + M2 type, which secretes pro-inflammatory cytokines such as IL-6, COX-2, and TGF- contributing to the inflammation and fibrosis underlying these lesions [45]

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This dual action has been demonstrated consistently in obese rodent models

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