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doi: 10.1007/s10517-008-0121-7

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Reducing viral antigen production reduces qHBsAg levels by up to 3 log, which might be sustained off therapy, and in combination with replication inhibitors or immunotherapy can achieve HBsAg loss in some instances, although not all are sustained
There is also the circumstance when someone has another diagnosis, such as Lyme disease, but treatments have been ineffective in resolving symptoms
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