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Cell Res (2021) 31:10725

demonstrated that the disruption of mitochondrial pyruvate carrier downregulates GSH metabolism, with lethal effects on carcinoma-induced hepatocytes [335]

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Oxidative stress induces apoptosis in embryonic cortical neurons

In other words, by maintaining the supply of available actin monomers, TB-500 provides a fast reaction for cell movement in the direction of the signal to migrate