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Clinical studies have reported strong correlations between oxidative stress biomarkers, such as malondialdehyde (MDA), and intestinal barrier injury markers, such as I-FABP, in sepsis patients ( Mitochondria, the primary energy factories of the cell, play a central role in apoptosis mediated by mitochondrial dysfunction, which is a key driver of multiple organ dysfunction syndrome (MODS) in sepsis (Tbara et al., 2025

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In contrast, a greater proportion of iCAFs was observed in PA10 samples (pCR sample), indicating that iCAFs may play a role in tissue reconstruction following tumor necrosis

It is found in roughly the same low concentration, both intracellularly and extracellularly

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