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Notably, many reported ferroptosis related agents (e.g., sorafenib, erastin) were not specifically designed to induce ferroptosis, and their effects often involve crosstalk among multiple cell death or signaling pathways, complicating mechanistic interpretation and clinical application

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Furthermore, selenium deficiency has been shown to predict prolonged ICU stays, higher infection rates, and increased hospital costs, underscoring its clinical and economic implications in critical care [4,6,11,52]

New mutations or altered expression patterns were associated with the development of acquired resistance against targeted therapy

NAD supports cellular repair, metabolism, and DNA health, helping to reduce signs of aging and improve overall vitality

Quercetin is proven to be therapeutic on cutaneous eczema, a kind of skin disease characterised by inflammation