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Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

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Elife 10 , e63326 (2021)

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It was also found that Quercetin can effectively inhibit the expression of miR-223-3p in AF model cells and rat myocardial tissue, enhance the expression of FOXO3, activate autophagy pathway, significantly inhibit myocardial fibrosis, and improve myocardial remodeling in AF (44)