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Phase I clinical trials of UCB0599 further confirmed its ability to cross the bloodbrain barrier rapidly and distribute into cerebrospinal fluid, with predominant localization in white and gray matter

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3) were analysed by area, as described in Materials and Methods

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Thus, accumulation of the PDC reaction products, acetyl CoA and NADH, or the end product of OXPHOS, ATP, increase PDK activity and suppress PDC through phosphorylation at one or more serine residues on E1

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