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Description

Stresul oxidativ contribuie la mbtrnirea prematur a esuturilor prin pierderea rezistenei i elasticitii acestora, la scderea activitii enzimatice, ct i n dezvoltarea diverselor forme de cancer (cauzat de mutaiile produse de radicalii liberi la nivelul ADN-ului celular, care determin activarea genelor oncogene i inactivarea genei oncosupresoare p53 [1]), n dezvoltarea bolilor cardiovasculare, bolilor inflamatorii, artritei, a fibrozei pulmonare sau a bolilor neurodegenerative precum Alzheimer i Parkinson

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Collectively, ATRA-ATO-NPs offer a mechanistically targeted, systemically safe, and highly effective strategy for advanced oncotherapy through dual-site spatiotemporal and simultaneous Pin1 inhibition