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In addition, natural activators of NRF2, such as indole, diterpenes, coumarin and lactone, alleviate renal cell death induced by lipid peroxidation [213]

Among the molecular targets affected by increased expression of GPx-1, it has been shown that GPx-1 may modify the ratio of Bax:Bcl-2 to create a more antiapoptotic environment (120)

The suppression of NF-B activation by various probiotics consequently diminishes the production of these mediators, leading to an attenuated inflammatory response (254)

Biomolecules 14 (12), 1556

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