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However, liver diseases, regardless of the cause, share many pathophysiological features like oxidative stress, post-translational modifications (PTMs), fat accumulation, metabolic signaling alterations, mitochondrial dysfunction, gut barrier dysfunction, inflammation, and hepatocyte apoptosis

In the near future, we are likely to see increasingly sophisticated preclinical models of irAEs, risk stratification with irAE biomarkers, and evidence based approaches for the management of irAE subsets such as steroid-refractory disease (Fig

International Human Genome Sequencing Consortium

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The raw protein intensity will be normalized by method "medium", Hierarchical clustering was performed using pheatmap package

Although the variants have changed [4], there is still potential for neuropsychiatric sequelae, and a large cohort study identified an equal potential of neuropsychiatric consequences comparing omicron versus delta variants [5]