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The MyD88-mediated TRIF activation of TLR downstream pathways triggers the nuclear translocation of NF-B, IFN regulatory factor 3 (IRF-3), and IFN regulatory factor 7 (IRF-7), resulting in the expression of innate immunity proinflammatory cytokines (interleukin-1 [IL-1], interleukin-6 [IL- 6], TNF-) and interferons (IFNs)

Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes

In conclusion, the present study provides compelling evidence, supported by the obtained results, for the efficacy of nanodispersions of lutein and beta-carotene in treating FM-related symptoms induced by reserpine in animal models