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In models of ovarian and liver cancer, NRF2 signaling enhances resistance to inducers like erastin and sorafenib (97, 98), whereas its loss or inhibition increases sensitivity

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Safety Toxicity High doses (10,000 to 16,000 mg/day) of choline have been associated with a fishy body odor, vomiting, salivation, and increased sweating

Multi-Organ Hypersensitivity Reactions: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), also known as Multi-organ hypersensitivity reactions, has been rarely reported in close temporal association after the initiation of valproate therapy in adult and pediatric patients (median time to detection 21 days