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However, one needs to evaluate whether they also modulate the expression of immune checkpoint proteins in tumor cells and contribute to immune escape

In rats, there were dose-related increases in nasal adenocarcinomas and squamous cell carcinomas (significant at all doses of 1350 mg/m 3 and greater) (Woutersen et al., 1986) and non significant increases in laryngeal and nasal carcinomas in hamsters (Feron et al., 1982)

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In human breast cancer MCF7 cells, copper ions increase the expression of TP53 [93]

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