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Concomitant short-chain fatty acid deficits, particularly butyrate loss from Akkermansia muciniphila depletion, impair BBB claudin-5 expression and neuronal mitochondrial biogenesis [57, 58]

[25] There is evidence from an in vitro study to suggest that the introduction of specific varied preparations containing orlistat, namely the concurrent administration of orlistat and the monoclonal antibody trastuzumab, can induce cell death in breast cancer cells and block their growth

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