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Article highlights: CYP2D6 is estimated to contribute to the metabolism of approximately 2025% of drugs

Semin Immunol (2013) 25:35863

Even though methylation is the most examined chemical alteration till date, other less abundant forms of modifications, such as 5-hydroxymethlcytosine ( 5-hmC ), 5-formylcytosine ( 5-fC ), and 5-carboxycytosine ( 5-caC ) have now been described in specific contexts

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