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Intriguingly, populations living in these regions consumed flour derived from the seeds of cycad plants Cycas micronesica , C

Ries S, Shahid A, Pedroza C, Hooda Z, Mitchell KG, Antonoff M , Hofstetter W, Mehran R, Rajaram R, Swisher S, Walsh G, Vaporciyan A, Rice D

9 When patients present relatively late after ingestion, oral N-acetylcysteine protocols provide a higher dose given over a longer period, which may be an advantage

Abbreviations 3-MST: 3-Mercaptopyruvate sulfurtransferase ALF: Acute liver failure AOAA: Aminooxyacetic acid CARS: Cysteinyl-tRNA synthetase CAT: Cysteine aminotransferase CBS: Cystathionine -synthase CNS: Central nervous system CO: Carbon monoxide CoQ: Coenzyme Q CSE: Cystathionine -lyase ETC: Electron transport chain ETHE1: Ethylmalonic encephalopathy 1 GalN: d-Galactosamine GSH: Glutathione GSSH: Glutathione persulfide H 2 S: Hydrogen sulfide HC: Hydroxocobalamin I/R: Ischemia/reperfusion LPS: Lipopolysaccharide MetHb: Methemoglobin NO: Nitric oxide O 2 : Oxygen PAG: dl-Propargyl glycine PLP: Pyridoxal 5-phosphate SDO: Sulfide dioxygenase SO: Sulfite oxidase SOU: Sulfide oxidation unit SQR: Sulfide quinone oxidoreductase STS: Sodium thiosulfate TNF-: Tumor necrosis factor TST: Rhodanese or thiosulfate sulfurtransferase References Reiffenstein RJ, Hulbert WC, Roth SH (1992) Toxicology of hydrogen sulfide

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In one of these cases, the mother reported eating fava beans 4 days prior to neonatal favism onset, which suggests that oxidative compounds derived from fava beans could be present in the breastmilk