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The most common adverse reactions in patients with sickle cell disease or other anemias (incidence 6%) are pyrexia, abdominal pain, bone pain, headache, vomiting, pain in extremity, sickle cell anemia with crisis, back pain, ALT increased, AST increased, arthralgia, oropharyngeal pain, nasopharyngitis, neutrophil count decreased, cough and nausea

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Severe muscle weakness or cramping, which can be a sign of low potassium that needs treating

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Recognising vitamin B12 deficiency early is crucial, as neurological damage may become irreversible if left untreated

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