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Description
This mechanism has been associated with diminished tumor growth in the preclinical models of head and neck cancer and pancreatic tumors

Its prevalence reaches 6070% in patients receiving paclitaxel [6], and despite scientists efforts during the last decades, no single effective therapeutic approach is currently available for preventing or treating CIPN [7]

The regulatory status varies by country and jurisdiction

Wolever TM, Zurbau A, Koecher K, Au-Young F

The localization of FUNDC1 at ER-mitochondria contact sites (MAMs) and its role in integrating mitophagy, mitochondrial adaptation, and ER stress responses exemplify how spatial organization determines functional proteostasis outcomes

CNS: Central nervous system
