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Nodules, eosinophilia, rheumatism, dermatitis and swelling (NERDS), episodic angioedema with eosinophilia (Gleich syndrome), urticaria, eosinophilic cellulitis (Wells syndrome), and insect bite reactions demonstrate variable degrees of edema that are probably explained, at least in part, by this mechanism (see Chapter 36)

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The synthetic version was designed to replicate those regulatory effects in a stable, injectable form

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