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In: Aronson J.K., editor

Further gel shift and reporter gene assays confirmed that they form a heterodimeric complex in vitro, bind to a specific DNA response element, and drive transcription in cells while responding to hypoxic signals

2009;23(Suppl 1):2131

These results suggest that THRSP may mediate T3-induced HCC inhibition and ENO2 downregulation by activating Raptor phosphorylation via the LKB1/AMPK pathway, which in turn suppresses mTOR activity and HIF-1 nuclear translocation in HCC

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As a potent and selective novel oral HIF-2 inhibitor, Welireg is an innovative therapy transformed from the Nobel Prize discovery, which once again emphasizes how science can benefit human health