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however, this phenomenon is accompanied by a continuous release of glutamate and substance P onto the second-order neurons, alongside diminished central levels of opioid peptides and serotonin [139,140]

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(PubMed) Hemila H

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Thymosin Alpha-1 and Immune Fatigue "Immune fatigue" is the lay term for a very real phenomenon: the state of being neither acutely ill nor well, characterised by low-grade inflammation, poor recovery, and elevated susceptibility to secondary infections

Feel free to share this pattern and blog with your doctor if they do not do a lot of Botox (or if you are not getting a good response!)