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Adjuvant therapies such as immunotherapy and radiotherapy may also be employed, though they have shown limited success in treating advanced-stage melanoma

Li et al., 2019

Intrinsic and acquired drug resistance in malignant tumors

Qiang Li, [email protected] These authors have contributed equally to this work This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The study outcomes The primary outcome was considered oocyte maturity rate that was defined as the ratio of metaphase II (MII) oocytes to the number of retrieved oocytes

Because TRP is a Ca 2+ channel activated downstream of phospholipase C, conjecture arose that it might represent the long-sought store-operated Ca 2+ channel (Hardie & Minke, 1993)