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Additional hurdles include the risk of off-target effects in mtDNA or the nuclear genome, potential immune responses to the editing machinery, and substantial technical and regulatory barriers that complicate translation of in vivo gene editing into clinical practice
10.1126/science.6658455 134 MaS.YangD.LiD.TangB.YangY
P.UchidaI.ItohY
Collin P, Reunala T, Pukkala E, Laippala P, Keyrilainen O, Pasternack A
The results obtained by these studies confirmed some previously discovered important characteristics of OR
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