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Nitric oxide is a well-established vasodilator - it causes smooth muscle relaxation in the walls of blood vessels, which dilates the vessels and reduces resistance to blood flow

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Prescribing for this indication is currently off-label but medically and legally appropriate when clinical criteria are met

Miyamoto et al

Mirpuri E, Garcia-Trevijano ER, Castilla-Cortazar I, Berasain C, Quiroga J, Rodriguez-Ortigosa C, Mato JM, Prieto J, Avila MA: Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I

doi:10.1212/CPJ.0000000000000043 While many studies have documented the short-term benefits of epidural steroid injections, the data on long-term effectiveness are less convincing