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A 2016 Health Canada technical report on drinking water found limited evidence that exposure to extremely alkaline water (pH greater than11) may cause skin or eye irritation

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However, there is a lack of research into interactions between brain chemistry changes and progression of migraine during the adolescent period

The results vary for each individual according to their body constitution

While there is adequate consensus on the modest efficacy of riluzole, there are still open questions concerning the efficacy of edaravone in slowing the disease progression