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James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH et al

Many different factors may contribute to ASD development

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Elevated tryptophan and reduced kynurenine levels were confirmed in these patients, disrupting serotonin and melatonin pathways and contributing to ME/CFS symptoms

The most effective strategy is slow dose escalation with 4-week holds

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