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When these conversions don't happen, then the body's blood stream is overloaded with a form of B12 it can't use or clear very quickly (hence you feel very bad afterwards)

This paradoxical response affects some patients receiving hydroxocobalamin treatment for vitamin B12 deficiency

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Information for Patients: Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives
