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There are also reports regarding its impact on thyroid function

Hyperplastic Skeletal Muscle Adaptation Known in research circles as the premier agent for studying "cell splitting," IGF-1 LR3 is used to observe how tissues adapt to perceived growth stress

Jeong, M

The pro-inflammatory milieu intensifies neuronal damage, compromises bloodbrain barrier integrity, and exacerbates reperfusion-induced damage

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Nature 377 , 649 (1995)