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3.2 Mechanisms of resistance to membrane-targeting antifungals: polyenes and azoles 3.2.1 Polyene antifungal antibiotics interact with cell membrane sterols Polyene antifungal agentssuch as nystatin, AMB, and natamycinare broad-spectrum drugs commonly used to treat opportunistic fungal infections caused by Candida , Cryptococcus , Aspergillus , and Lentinus species (Carolus et al., 2020

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Abbreviations AIF: Apoptosis-inducing factor BBB: Bloodbrain barrier CREB: CAMP response element-binding protein JNK: C-Jun-N-terminal kinases AcCoA: Coenzyme A COX-IV: Cytochrome c oxidase IV DCA: Dichloroacetate NAD + : Dinucleotide DRP1: Dynamin-Related Protein 1 HO-1: Heme Oxygenase-1 HS: Hemorrhagic stroke iNOS: Inducible nitric oxide synthase IL10: Interleukin 10 IL6: Interleukin- 6 IL-1: Interleukin-1beta iNOS: Inducible nitric oxide synthase IS: Ischemic stroke CD206: Mannose Receptor MMP9: Matrix metalloproteinase 9 Tfam: Mitochondrial transcription factor A Mfn1: Mitofusion-1 MYPT1: Myosin phosphatase target subunit 1 NO: Nitric oxide: Nrf2: Nuclear respiratory factor 2 Nrf-1: Nuclear respiratory factor Opa1: Optic Atrophy 1 p38 MAPK: P38 mitogen-activated protein kinase PCr: Phosphocreatine: PDH: Pyruvate dehydrogenase PDHC: Pyruvate dehydrogenase complex PDK: Pyruvate dehydrogenase kinase PDKs: Pyruvate dehydrogenase kinases RNS: Reactive nitrogen species ROS: Reactive oxygen species ROCK: Rho-associated protein kinase SQSTM1: Sequestosome 1 SOD: Superoxide dismutase: TCA: Tricarboxylic acid TNF-: Tumor Necrosis Factor- References Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, Fisher M, Pandian J, Lindsay P