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Inflammatory caspases are innate immune receptors for intracellular LPS

TNF-a decreases the availability of reduced glutathione, resulting in an increase in local oxidation stress, and at the same time sensitizes the membrane of the cell to increased damage from oxidation stress

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In mouse murine pro-lymphoid (BaF3) cells with mutated JAK2 displayed significantly enhanced glutaminase metabolism and increased expression of GLS compared to wild-type cells [107]

Structural Types and Sources As natural compounds, flavonoids are representative compounds that exert antitumor effects by regulating abnormal metabolic networks

Cerebellar Microglia and Neuronal Pathology Cerebellar inflammation, neuronal loss, and associated functional impairments are observed in both patients and animal models of various brain and systemic disorders, including ataxias, neurodegeneration, autism spectrum disorders (ASD), metabolic pathologies, and aging (Smith et al., 2019