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The ~600-kDa trimeric S proteins can bind to ACE2 through the RBD required for membrane fusion (see Fig

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doi: 10.1146/annurev-immunol-041015-055318 3 PearceELPoffenbergerMCChangCH

Rather than treating ferroptosis as a uniform vulnerability, clinical translation will probably succeed where patients can be stratified by (1) the architecture of antioxidant defenses (for example, FSP1/GPX4 balance), (2) the size and distribution of cellular CoQ pools, (3) lipid composition and peroxidation-prone membranes and (4) oncogenic programs that remodel redox metabolism (such as NRF2KEAP1)

Post washing, the grids were stained with 0.5% uranyl acetate in water, subjected to EM, and imaged with a Jeol1400 at an acceleration voltage of 120 kV

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