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2 However, it was reported in a study 43 conducted with a human colon model that the choline--butyrobetaine-TMA pathway is not active for TMA production from choline in humans, and choline is directly metabolized to TMA by the TMA lyase pathway

It may be expressed in response to cellular stress.43 Some common nevi may express little p16 without this indicating inactivation of CDKN2A

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